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C-reactive protein ...
C-reactive protein and C1q regulate platelet adhesion and activation on adsorbed immunoglobulin G and albumin.
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- Skoglund, Caroline, 1981- (författare)
- Linköpings universitet,Hälsouniversitetet,Farmakologi
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- Wetterö, Jonas, 1972- (författare)
- Linköpings universitet,Hälsouniversitetet,Reumatologi
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- Skogh, Thomas, 1952- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Reumatologi,Länskliniken för Reumatologi i Östergötland
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- Sjöwall, Christopher, 1975- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland
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- Tengvall, Pentti (författare)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Physics, Chemistry and Biology, Materials in Medicine, Division of Applied Physics, Linköping University, Linköping, Sweden,Tekniska högskolan,Tillämpad Fysik
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- Bengtsson, Torbjörn, 1955- (författare)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Hälsouniversitetet
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(creator_code:org_t)
- 2008-03-11
- 2008
- Engelska.
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Ingår i: Immunology and cell biology. - : Wiley. - 0818-9641 .- 1440-1711. ; 86:5, s. 466-74
- Relaterad länk:
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https://doi.org/10.1...
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http://www.ncbi.nlm....
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Blood platelets and C-reactive protein (CRP) are both used clinically as markers of ongoing inflammation, and both participate actively in inflammatory responses, although the biological effects are still incompletely understood. Rapidly adhering platelets express receptors for complement factor 1q (C1q) and the Fc part of immunoglobulin G (IgG), and CRP is known to activate/regulate complement via C1q binding, and to ligate FcgammaRs. In the present study, we used normal human IgG pre-adsorbed to a well-characterized methylated surface as a model solid-phase immune complex when investigating the effects of CRP and C1q on platelet adhesion and activation. Protein adsorption was characterized using ellipsometry and polyclonal antibodies, and human serum albumin (HSA) and non-coated surfaces were used as reference surfaces. Platelet adhesion to IgG and HSA was inhibited by both C1q and CRP. Furthermore, CRP (moderately) and C1q (markedly) decreased the spreading of adhering platelets. The combination of C1q and CRP was slightly more potent in reducing cell adhesion to IgG, and also impaired the adhesion to HSA and non-coated surfaces. Platelet production of thromboxane B2 (TXB(2)) was also reduced by C1q both in the presence and absence of CRP, whereas CRP alone had no effect on TXB(2) production. We conclude that CRP and C1q regulate the behaviour of platelets, and that this may be an important immunoregulatory mechanism during inflammatory conditions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Blood Platelets
- cytology
- drug effects
- immunology
- metabolism
- C-Reactive Protein
- pharmacology
- Cell Shape
- Complement C1q
- pharmacology
- Humans
- Immunoglobulin G
- immunology
- Phosphatidylserines
- metabolism
- Platelet Activation
- drug effects
- Platelet Adhesiveness
- drug effects
- Serum Albumin
- metabolism
- Thromboxane B2
- biosynthesis
- secretion
- acute-phase response; C-reactive protein (CRP); complement; inflammation; plasma protein adsorption; platelets
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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