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Cytotoxic crossmatc...
Abstract
Ämnesord
Stäng
- The predictive value of cytotoxic crossmatch analysis before allo-SCT remains unclear. We retrospectively analyzed the clinical impact of cytotoxic T- and B-cell crossmatch testing before allo-SCT between January 2000 and June 2005. Cytotoxic crossmatches were performed in 157 patients receiving stem cells from matched unrelated donors or an HLA-A, -B or -DRB1 allele mismatched graft. Ninety patients are still alive. Eleven patients rejected their grafts. One of 11 patients with rejection was positive in a T-cell crossmatch before allo-SCT and 4 of 11 in B-cell crossmatches. T-cell crossmatches showed a sensitivity of 9% and a specificity of 97% compared with 36 and 86% for B-cell crossmatches. Positive T- and/or B-crossmatch before SCT had no predictive value for survival in this study as compared with patients with a negative crossmatch. In conclusion, the pretransplant cytotoxic T- and/or B-crossmatch is a poor predictor of rejection after allo-SCT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Aged
- B-Lymphocytes
- immunology
- Child
- Child
- Preschool
- Female
- Graft Rejection
- immunology
- Graft Survival
- immunology
- Histocompatibility Testing
- Humans
- Infant
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Risk Factors
- Stem Cell Transplantation
- methods
- T-Lymphocytes
- immunology
- Transplantation
- Homologous
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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