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The effect of study...
The effect of study arm on prostate cancer treatment in the large screening trial ERSPC.
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Wolters, Tineke (författare)
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Roobol, Monique J (författare)
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Steyerberg, Ewout W (författare)
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van den Bergh, Roderick C N (författare)
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Bangma, Chris H (författare)
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- Hugosson, Jonas, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Ciatto, Stefano (författare)
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Kwiatkowski, Maciej (författare)
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Villers, Arnauld (författare)
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Luján, Marcos (författare)
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Nelen, Vera (författare)
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Tammela, Teuvo L J (författare)
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Schröder, Fritz H (författare)
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(creator_code:org_t)
- Wiley, 2010
- 2010
- Engelska.
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Ingår i: International journal of cancer. Journal international du cancer. - : Wiley. - 1097-0215. ; 126:10, s. 2387-93
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Prostate cancer (PC) mortality is the most valid end-point in screening trials, but could be influenced by the choice of initial treatment if treatment has an effect on mortality. In this study, PC treatment was compared between the screening and control arms in a screening trial. Data were collected from the European Randomized Study of Screening for Prostate Cancer (ERSPC). The characteristics and initial treatment of PC cases detected in the screening and the control arm were compared. Polytomous logistic regression analysis was used to assess the influence of study arm on treatment, adjusting for potential confounders and with statistical imputation of missing values. A total of 8,389 PC cases were detected, 5,422 in the screening arm and 3,145 in the control arm. Polytomous regression showed that trial arm was associated with treatment choice after correction for missing values, especially in men with high-risk PC. A control subject with high-risk PC was more likely than a screen subject to receive radiotherapy (OR: 1.43, 95% CI: 1.01-2.05, p = 0.047), expectant management (OR: 2.92, 95% CI: 1.33-6.42, p = 0.007) or hormonal treatment (OR: 1.77, 95% CI: 1.07-2.94, p = 0.026) instead of radical prostatectomy. However, trial arm had only a minor role in treatment choice compared to other variables. In conclusion, a small effect of trial arm on treatment choice was seen, particularly in men with high-risk PC. Therefore, differences in treatment between arms are unlikely to play a major role in the interpretation of the results of the ERSPC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Aged
- Androgen Antagonists
- therapeutic use
- Antineoplastic Agents
- Hormonal
- therapeutic use
- Europe
- Humans
- Logistic Models
- Male
- Mass Screening
- Middle Aged
- Multivariate Analysis
- Neoplasm Staging
- Odds Ratio
- Prostatectomy
- methods
- Prostatic Neoplasms
- diagnosis
- drug therapy
- pathology
- radiotherapy
- surgery
- therapy
- Risk Assessment
- Risk Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wolters, Tineke
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Roobol, Monique ...
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Steyerberg, Ewou ...
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van den Bergh, R ...
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Bangma, Chris H
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Hugosson, Jonas, ...
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visa fler...
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Ciatto, Stefano
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Kwiatkowski, Mac ...
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Villers, Arnauld
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Luján, Marcos
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Nelen, Vera
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Tammela, Teuvo L ...
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Schröder, Fritz ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Urologi och njur ...
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International Jo ...
- Av lärosätet
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Göteborgs universitet