Improved cardiac performance by rosuvastatin is associated with attenuations in both myocardial tumor necrosis factor-alpha and p38 MAP kinase activity in rats after myocardial infarction.

• Statins have been shown to exert anti-inflammatory effects. The aim of this study was to investigate whether rosuvastatin has favorable effect on ventricular remodeling after myocardial infarction (MI), whether this effect is associated with tumor necrosis factor (TNF)-alpha expression and p38 mitogen-activated protein (MAP) kinase pathway and, furthermore, whether there is close correlation between gene expression of TNF-alpha and activity of p38 MAP kinase.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

Animals

Blood Pressure

drug effects

physiology

Blotting

Western

Cholesterol

blood

Echocardiography

Fluorobenzenes

pharmacology

therapeutic use

Heart

drug effects

physiopathology

Heart Rate

drug effects

physiology

Hydroxymethylglutaryl-CoA Reductase Inhibitors

pharmacology

therapeutic use

Lipoproteins

HDL

blood

Lipoproteins

LDL

blood

Male

Myocardial Infarction

drug therapy

pathology

physiopathology

Myocardium

chemistry

pathology

Pyrimidines

pharmacology

therapeutic use

Rats

Rats

Wistar

Reverse Transcriptase Polymerase Chain Reaction

Sulfonamides

pharmacology

therapeutic use

Triglycerides

blood

Tumor Necrosis Factor-alpha

analysis

biosynthesis

Ventricular Remodeling

drug effects

physiology

p38 Mitogen-Activated Protein Kinases

analysis

biosynthesis

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)