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Serotonin and its m...
Serotonin and its metabolism in basal deuterostomes: insights from Strongylocentrotus purpuratus and Xenoturbella bocki
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Squires, L. N. (författare)
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Rubakhin, S. S. (författare)
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Wadhams, A. A. (författare)
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Talbot, K. N. (författare)
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- Nakano, Hiroaki, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för marin ekologi,Department of Marine Ecology
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Moroz, L. L. (författare)
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Sweedler, J. V. (författare)
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(creator_code:org_t)
- The Company of Biologists, 2010
- 2010
- Engelska.
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Ingår i: Journal of Experimental Biology. - : The Company of Biologists. - 0022-0949 .- 1477-9145. ; 213:15, s. 2647-2654
- Relaterad länk:
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http://jeb.biologist...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Serotonin (5-HT), an important molecule in metazoans, is involved in a range of biological processes including neurotransmission and neuromodulation. Both its creation and release are tightly regulated, as is its removal. Multiple neurochemical pathways are responsible for the catabolism of 5-HT and are phyla specific; therefore, by elucidating these catabolic pathways we glean greater understanding of the relationships and origins of various transmitter systems. Here, 5-HT catabolic pathways were studied in Strongylocentrotus purpuratus and Xenoturbella bocki, two organisms occupying distinct positions in deuterostomes. The 5-HT-related compounds detected in these organisms were compared with those reported in other phyla. In S. purpuratus, 5-HT-related metabolites include N-acetyl serotonin, gamma-glutamyl-serotonin and 5-hydroxyindole acetic acid; the quantity and type were found to vary based on the specific tissues analyzed. In addition to these compounds, varying levels of tryptamine were also seen. Upon addition of a 5-HT precursor and a monoamine oxidase inhibitor, 5-HT itself was detected. In similar experiments using X. bocki tissues, the 5-HT-related compounds found included 5-HT sulfate, gamma-glutamyl-serotonin and 5-hydroxyindole acetic acid, as well as 5-HT and tryptamine. The sea urchin metabolizes 5-HT in a manner similar to both gastropod mollusks, as evidenced by the detection of gamma-glutamyl-serotonin, and vertebrates, as indicated by the presence of 5-hydroxyindole acetic acid and N-acetyl serotonin. In contrast, 5-HT metabolism in X. bocki appears more similar to common protostome 5-HT catabolic pathways.
Ämnesord
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
Nyckelord
- indoleamine
- capillary electrophoresis
- neurotransmitters
- catabolism
- CAPILLARY-ELECTROPHORESIS
- PHYLUM XENOTURBELLIDA
- BIOGENIC-AMINES
- SEA-URCHIN
- APLYSIA-CALIFORNICA
- MONOAMINE-OXIDASE
- NERVOUS SYSTEMS
- 5-HYDROXYTRYPTAMINE
- CATABOLISM
- EMBRYOS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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