Search: id:"swepub:oai:gup.ub.gu.se/134759" >
Glucocorticoids sup...
Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor.
-
Rauch, Alexander (author)
-
Seitz, Sebastian (author)
-
Baschant, Ulrike (author)
-
show more...
-
Schilling, Arndt F (author)
-
Illing, Anett (author)
-
Stride, Brenda (author)
-
Kirilov, Milen (author)
-
Mandic, Vice (author)
-
Takacz, Andrea (author)
-
Schmidt-Ullrich, Ruth (author)
-
Ostermay, Susanne (author)
-
Schinke, Thorsten (author)
-
Spanbroek, Rainer (author)
-
Zaiss, Mario M (author)
-
Angel, Peter E (author)
-
- Lerner, Ulf H (author)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine,Oral cellbiologi
-
David, Jean-Pierre (author)
-
Reichardt, Holger M (author)
-
Amling, Michael (author)
-
Schütz, Günther (author)
-
Tuckermann, Jan P (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
-
In: Cell metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 11:6, s. 517-31
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Development of osteoporosis severely complicates long-term glucocorticoid (GC) therapy. Using a Cre-transgenic mouse line, we now demonstrate that GCs are unable to repress bone formation in the absence of glucocorticoid receptor (GR) expression in osteoblasts as they become refractory to hormone-induced apoptosis, inhibition of proliferation, and differentiation. In contrast, GC treatment still reduces bone formation in mice carrying a mutation that only disrupts GR dimerization, resulting in bone loss in vivo, enhanced apoptosis, and suppressed differentiation in vitro. The inhibitory GC effects on osteoblasts can be explained by a mechanism involving suppression of cytokines, such as interleukin 11, via interaction of the monomeric GR with AP-1, but not NF-kappaB. Thus, GCs inhibit cytokines independent of GR dimerization and thereby attenuate osteoblast differentiation, which accounts, in part, for bone loss during GC therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Animals
- Apoptosis
- Cell Differentiation
- Dimerization
- Glucocorticoids
- toxicity
- Interleukin-11
- metabolism
- Mice
- Mice
- Knockout
- Osteoblasts
- cytology
- drug effects
- Osteogenesis
- drug effects
- Receptors
- Glucocorticoid
- genetics
- metabolism
- Transcription Factor AP-1
- metabolism
- induced osteoporosis; gene-expression; dna-binding; cell-cycle; mice; inhibition; interleukin-11; osteoclast; mechanisms; phenotype
- Cell biology
- odontologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Rauch, Alexander
-
Seitz, Sebastian
-
Baschant, Ulrike
-
Schilling, Arndt ...
-
Illing, Anett
-
Stride, Brenda
-
show more...
-
Kirilov, Milen
-
Mandic, Vice
-
Takacz, Andrea
-
Schmidt-Ullrich, ...
-
Ostermay, Susann ...
-
Schinke, Thorste ...
-
Spanbroek, Raine ...
-
Zaiss, Mario M
-
Angel, Peter E
-
Lerner, Ulf H
-
David, Jean-Pier ...
-
Reichardt, Holge ...
-
Amling, Michael
-
Schütz, Günther
-
Tuckermann, Jan ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Cell metabolism
- By the university
-
University of Gothenburg
-
Umeå University