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Nuclear Janus-activ...
Nuclear Janus-activated kinase 2/nuclear factor 1-C2 suppresses tumorigenesis and epithelial-to-mesenchymal transition by repressing Forkhead box F1.
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- Nilsson, Jeanette, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, molekylärbiologi,Department of Cell and Molecular Biology, Molecular Biology
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- Helou, Khalil, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Institute of Clinical Sciences, Department of Oncology
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Kovács, Anikó, 1961 (författare)
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- Bendahl, Pär-Ola (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Bjursell, Gunnar, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, molekylärbiologi,Department of Cell and Molecular Biology, Molecular Biology
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- Fernö, Mårten (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Carlsson, Peter, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology
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- Kannius-Janson, Marie, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, molekylärbiologi,Department of Cell and Molecular Biology, Molecular Biology
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(creator_code:org_t)
- 2010
- 2010
- Engelska.
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Ingår i: Cancer research. - 1538-7445. ; 70:5, s. 2020-2029
- Relaterad länk:
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http://www.ncbi.nlm.... (free)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Progression to metastasis is the proximal cause of most cancer-related mortality. Yet much remains to be understood about what determines the spread of tumor cells. This paper describes a novel pathway in breast cancer that regulates epithelial-to-mesenchymal transition (EMT), motility, and invasiveness. We identify two transcription factors, nuclear factor 1-C2 (NF1-C2) and Forkhead box F1 (FoxF1), downstream of prolactin/nuclear Janus-activated kinase 2, with opposite effects on these processes. We show that NF1-C2 is lost during mammary tumor progression and is almost invariably absent from lymph node metastases. NF1-C2 levels in primary tumors correlate with better patient survival. Manipulation of NF1-C2 levels by expression of a stabilized version or using small interfering RNA showed that NF1-C2 counteracts EMT, motility, invasiveness, and tumor growth. FoxF1 was found to be a direct repressed target of NF1-C2. We provide the first evidence for a role of FoxF1 in cancer and in the regulation of EMT in cells of epithelial origin. Overexpression of FoxF1 was associated with a mesenchymal phenotype, increased invasiveness in vitro, and enhanced growth of breast carcinoma xenografts in nude mice. The relevance of these findings is strengthened by the correlation between FoxF1 expression and a mesenchymal phenoype in breast cancer cell isolates, consistent with the interpretation that FoxF1 promotes invasion and metastasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Animals
- Breast Neoplasms
- genetics
- metabolism
- pathology
- Cell Adhesion
- physiology
- Cell Growth Processes
- physiology
- Cell Line
- Tumor
- Cell Movement
- physiology
- Epithelial Cells
- pathology
- Female
- Forkhead Transcription Factors
- antagonists & inhibitors
- biosynthesis
- genetics
- metabolism
- Humans
- Janus Kinase 2
- metabolism
- Mesoderm
- pathology
- Mice
- Mice
- Inbred BALB C
- Mice
- Nude
- NFI Transcription Factors
- metabolism
- Promoter Regions
- Genetic
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Nilsson, Jeanett ...
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Helou, Khalil, 1 ...
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Kovács, Anikó, 1 ...
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Bendahl, Pär-Ola
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Bjursell, Gunnar ...
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Fernö, Mårten
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visa fler...
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Carlsson, Peter, ...
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Kannius-Janson, ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Cancer research
- Av lärosätet
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Göteborgs universitet
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Lunds universitet