Shunt surgery in patients with hydrocephalus and white matter changes.

• Patients with idiopathic normal pressure hydrocephalus (iNPH) often present with impaired gait and cognition together with ventricular enlargement and normal intracranial pressure. Many have vascular risk factors as well as periventricular and deep white matter changes on MR imaging. Abnormal CSF dynamics, that is, high resistance to outflow or improvement after CSF drainage, indicate good effects of shunt surgery. The authors examined whether the worst-case iNPH patients with extensive vascular white matter disease and normal CSF dynamics would benefit from shunt surgery. These patients also fulfilled the criteria for Binswanger disease. Therefore, a randomized controlled double-blind study was performed.

Nyckelord

Aged

Aged

80 and over

Brain

pathology

Cerebrospinal Fluid Pressure

physiology

Comorbidity

Dementia

Vascular

diagnosis

surgery

Female

Follow-Up Studies

Gait Disorders

Neurologic

etiology

Humans

Hydrocephalus

Normal Pressure

diagnosis

surgery

Image Processing

Computer-Assisted

Ligation

Magnetic Resonance Imaging

Male

Middle Aged

Neurologic Examination

statistics & numerical data

Neuropsychological Tests

statistics & numerical data

Postoperative Complications

etiology

Psychometrics

Ventriculoperitoneal Shunt

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)