On safety, pharmacokinetics and dosage of bevacizumab in ROP treatment - a review.

• Off label intravitreal use of the VEGF antibody bevacizumab for retinopathy of prematurity (ROP) increases despite lack of studies on safety, pharmacokinetics and dosage in developing individuals. Systemic absorption has been considered negligible. A literature search was performed with emphasis on potential adverse systemic effects in developing individuals. Intravitreal bevacizumab enters the general circulation, suppresses plasma VEGF levels and remains in the blood for more than 8 weeks in primates. Possible adverse effects on VEGF dependent development must be considered.

Nyckelord

Anti-vascular endothelial growth factor; Bevacizumab; Pharmacokinetics; Retinopathy of prematurity

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