Depression in Myotonic Dystrophy type 1: clinical and neuronal correlates.

• Background This study was designed to investigate the prevalence and correlates of depression in Myotonic dystrophy type 1 (DM1). Methods Thirty-one patients with DM1 and 47 subjects in a clinical contrast group, consisting of other neuromuscular disorders, including Spinal muscular atrophy, Limb girdle muscle atrophy and Facioscapulohumeral dystrophy, completed Beck Depression Inventory (BDI). We aimed to establish whether different factors associated with DM1 correlated with ratings in the BDI. Results Signs of a clinical depression were prevalent in 32% of the patients with DM1, which was comparable with ratings in the clinical contrast group. The depressive condition was mild to moderate in both groups. In DM1, a longer duration of clinical symptoms was associated with lower scores on the BDI and higher educational levels were correlated with higher scores on depression. We also found a negative association with brain white matter lesions. Conclusions Findings indicate significantly more DM1 patients than normative collectives showing signs of a clinical depression. The depressive condition is however mild to moderate and data indicate that the need for intervention is at hand preferentially early during the disease process.

Nyckelord

Adolescent

Adult

Brain

pathology

Depressive Disorder

epidemiology

pathology

Female

Humans

Magnetic Resonance Imaging

Male

Middle Aged

Muscular Atrophy

Spinal

epidemiology

pathology

Muscular Dystrophies

Limb-Girdle

epidemiology

pathology

Muscular Dystrophy

Facioscapulohumeral

epidemiology

pathology

Myotonic Dystrophy

epidemiology

pathology

Nerve Fibers

Myelinated

pathology

Prevalence

Psychiatric Status Rating Scales

Risk Factors

Young Adult

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)