The effect of hydroxyapatite nanocrystals on early bone formation surrounding dental implants.

• The knowledge of how nanostructures might affect early bone healing and osseointegration is limited. The aim of this study was to investigate if nanometer thick coatings of hydroxyapatite nanocrystals applied on a moderately rough surface might enhance early bone healing on screw-shaped dental implants and to evaluate if the thickness of the coat influences healing. Sandblasted and acid etched titanium implants coated with two different thicknesses of hydroxyapatite (test implants) and sandblasted and acid etched titanium implants (control implants), were inserted in rabbit tibia. After a healing time of 2, 4 and 9 weeks, a removal torque analysis and a histological evaluation were performed. The results from the removal torque analysis showed a tendency for higher values for the double coated hydroxyapatite after 4 weeks and for both the coated surfaces after 9 weeks of healing. The histological evaluations indicated slightly more new bone formation with the coated implants compared with the control; the differences did not reach statistical significance. The present study could not support the importance of nanometer thick coatings of hydroxyapatite nanocrystals in early bone healing, at least not when applied on a blasted and etched surface and placed in a cortical bone.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Nyckelord

Acid Etching

Dental

Animals

Coated Materials

Biocompatible

chemistry

Dental Etching

Dental Implants

Dental Materials

chemistry

Dental Prosthesis Design

Durapatite

chemistry

Materials Testing

Microscopy

Electron

Scanning

Models

Animal

Nanoparticles

chemistry

Osseointegration

physiology

Osteogenesis

physiology

Photoelectron Spectroscopy

Rabbits

Surface Properties

Tibia

pathology

surgery

Time Factors

Titanium

chemistry

Torque

nanostructures

surface topography

hydroxyapatite coat

dental

implants

in vivo study

acid-etched surface

titanium implants

calcium-phosphate

in-vitro

osteoblast adhesion

enhanced functions

removal torque

oral implants

coatings

vivo

pathology

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