Cyclooxygenase-2 inhibition does not improve the reduction in ductal carcinoma in situ proliferation with aromatase inhibitor therapy: results of the ERISAC randomized placebo-controlled trial.

• Tamoxifen reduces risk of recurrence after breast conservation surgery for ductal carcinoma in situ (DCIS), but no data exists on the effectiveness of aromatase inhibitors for DCIS. Cyclooxygenase-2 (COX-2) is overexpressed in DCIS, representing another potential therapeutic target. The aim of the study was to determine the effect of aromatase and/or COX-2 inhibition on epithelial proliferation and apoptosis in a presurgical study of estrogen receptor (ER)-positive DCIS. Methods: Postmenopausal women with ER-positive DCIS diagnosed by core biopsy were randomized to a 2 x 2 design of either 14 days of exemestane or placebo and celecoxib, or placebo immediately before surgery. Paired baseline and end point biopsies were analyzed for proliferation (Ki67), apoptosis, human epidermal growth factor receptor 2 (HER2), COX-2, and progesterone receptor (PR) expression by immunohistochemistry. The primary end point was a decrease in Ki67 between diagnosis and surgical excision.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Androstadienes

administration & dosage

Antineoplastic Combined Chemotherapy Protocols

therapeutic use

Apoptosis

drug effects

Aromatase Inhibitors

therapeutic use

Breast Neoplasms

drug therapy

genetics

pathology

Carcinoma in Situ

drug therapy

genetics

pathology

Carcinoma

Ductal

Breast

drug therapy

genetics

pathology

Cell Proliferation

drug effects

Cyclooxygenase 2

biosynthesis

drug effects

Female

Humans

Immunohistochemistry

Ki-67 Antigen

biosynthesis

Placebos

Pyrazoles

administration & dosage

Receptor

erbB-2

biosynthesis

drug effects

genetics

Receptors

Estrogen

biosynthesis

genetics

Receptors

Progesterone

biosynthesis

genetics

Sulfonamides

administration & dosage

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)