Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial.

• Objective: To investigate the possible effects of low-frequency electro-acupuncture (EA) and physical exercise on markers of coagulation and fibrinolysis, insulin sensitivity, and adipose tissue characteristics in women with PCOS. Design: Secondary analyses of a prospective, randomized controlled clinical trial. ClinicalTrials.gov (identifier NCT00484705) Settings: Department of Physiology and Department of Obstetrics and Gynecology, Universtiy of Gothenburg. Patients/Interventions: Eighty-four women with PCOS were randomized to sixteen weeks of low-frequency EA (14 treatments), physical exercise (at least 3 times/week) or no intervention. Main outcome measures: Anthropometrics, circulating coagulation and fibrinolytic markers, insulin sensitivity (euglycemic hyperinsulinemic clamp), hemodynamics, and adipose tissue morphology/function recorded at baseline, after 16 weeks of intervention, and after a 16 week follow-up. Results: In the low-frequency EA group, circulating plasminogen activator inhibitor (PAI-1) activity decreased by 21.8% after 16 weeks of intervention and by 31.1% at the 16 week follow-up and differed from the physical exercise and the no-intervention groups. The EA group had decreases in circulating fibrinogen and t-PA, sagittal diameter, and diastolic blood pressure after treatment, and fibrinogen remained lower at the 16-week follow-up. In the physical exercise group, lipoprotein lipase activity increased and diastolic blood pressure decreased after treatment, and both diastolic and systolic blood pressure were lower at follow-up. No other variables were affected. Conclusions: Low-frequency EA counteracted a possible prothrombotic state in women with PCOS, as reflected by a decrease in PAI-1 activity. Despite within-group improvements, there were no between-group differences in anthropometric, metabolic, or hemodynamic variables after 16 weeks of EA or physical exercise at the dose/intensity studied.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

polycystic ovary syndrome

exercise

acupuncture

insulin sensitivity

coagulation

Acupuncture

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