Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production.

• The non-structural (NS) 3/4A protease/helicase of the hepatitis C virus is known to modulate signalling pathways in the infected hepatocyte by cleaving CARD adaptor inducing IFNβ (Cardif), T-cell protein tyrosine phosphatase (TC-PTP) and TIR domain-containing adaptor inducing IFNβ (TRIF), but the effects of NS3/4A in vivo still remain unclear.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

Animals

Carrier Proteins

physiology

Case-Control Studies

Female

Hepacivirus

metabolism

Hepatitis C

immunology

Humans

Interferon-alpha

metabolism

Interferon-gamma

biosynthesis

pharmacology

Lipopolysaccharides

pharmacology

Liver

immunology

Lymphocyte Subsets

immunology

Male

Mice

Mice

Transgenic

Middle Aged

STAT1 Transcription Factor

metabolism

Signal Transduction

Viral Nonstructural Proteins

physiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)