Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy

• Objective: To To apply stereology for the detection of possibly morphological abnormalities in placentas of women with intrahepatic cholestasis of pregnancy (ICP). Study design: Prospective case-control study of placentas from untreated and UDCA-treated ICP, respectively, and normal pregnancies, examined for morphological differences by systematic random sampling generated by computerized stereology methodology. Main outcome measures: Volume of placenta, surface area of terminal villi and capillaries, volume fraction of collagen, number of syncytial knots, and chorangiosis. Results: Surface area of terminal villi and capillaries, and number of syncytial knots were higher in placentas from all ICP, as compared to controls (p < 0.01). A reduction of collagen was found in placentas from UDCA-treated ICP, both in comparison to placentas from untreated ICP and controls (p < 0.05). Conclusion: ICP affects the placenta morphologically as shown by increased terminal villous and capillary surface area, and number of syncytial knots. (c) 2012 Elsevier Ltd. All rights reserved.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

Intrahepatic cholestasis of pregnancy

Obstetric cholestasis

Placenta

Ursodeoxycholic acid

Bile

bile-acid levels

image-analysis

high-altitude

hypoxia

chorangiosis

microscopy

efficiency

sections

light

villi

Publikations- och innehållstyp

ref (ämneskategori)

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