Secondary hyperparathyroidism but stable bone-mineral density in patients with chronic myeloid leukemia treated with imatinib.

• Imatinib is currently the standard treatment for chronic myeloid leukemia(CML). Previous studies have shown that imatinib affects bone metabolism in CML patients. However, these effects are not well-studied prospectively. The authors studied bone-mineral density (BMD) and bone metabolism in 17 CML patients and matched controls in 2007 and now repeated the analyses prospectively in 2011. All CML patients were in complete cytogenetic remission during this 4-year period and treated with 400 mg imatinib q.d. (n 5 15) or 600 mg imatinib q.d. (n 5 2). Mean treatment duration was 102 months (range 69–129) in 2011. The authors found that serum levels of parathyroid hormone increased significantly in the patients between 2007 and 2011, and seven out of 17 patients had secondary hyperparathyroidism in 2011. However, the mean areal and volumetric BMDs were stable in the CML patients over the 4-year-observation period. Moreover, the CML patients had significantly higher volumetric BMD in the cortical compartment when compared with controls in 2011 and 2007. Thus, despite a high incidence of secondary hyperparathyroidism,there were no signs of osteoporosis or osteomalacia in imatinib-treated CML patients as suggested earlier.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

Aged

Alkaline Phosphatase

blood

Antineoplastic Agents

adverse effects

pharmacology

therapeutic use

Biological Markers

Bone Density

Calcium

blood

Collagen Type I

blood

Female

Humans

Hyperparathyroidism

Secondary

chemically induced

Leukemia

Myelogenous

Chronic

BCR-ABL Positive

blood

complications

drug therapy

Magnesium

blood

Male

Menopause

Middle Aged

Osteocalcin

blood

Parathyroid Hormone

blood

Peptides

blood

Piperazines

adverse effects

pharmacology

therapeutic use

Protein Kinase Inhibitors

adverse effects

pharmacology

therapeutic use

Pyrimidines

adverse effects

pharmacology

therapeutic use

Smoking

blood

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