A standardized template for clinical studies in preterm birth.

• Preterm birth is a major societal and economic problem accounting for 80 to 90% of neonatal morbidity and mortality worldwide. It is recognized as a complex multifactorial condition comprising several distinct clinical phenotypes with different underlying etiologies. As animal models are expensive and fail to mimic the biology of spontaneous preterm birth in humans, understanding the pathophysiology requires detailed clinical studies. Meta-analyses and clinical translation of data, however, are limited by heterogeneity of study design and size, publication and reporting biases, definition of patient groups, and a lack of standard universal definitions. This article provides a harmonized open-source template for designing clinical studies addressing preterm birth.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

Biomedical Research

Female

Gestational Age

Glucocorticoids

administration & dosage

Humans

Infant

Newborn

Infection

complications

Male

Obesity

complications

Phenotype

Pregnancy

Pregnancy Complications

Pregnancy

Multiple

Premature Birth

etiology

Research Design

standards

Sex Factors

Stress

Physiological

Stress

Psychological

complications

Uterine Cervical Diseases

complications

Uterine Diseases

complications

Uterine Hemorrhage

complications

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)