Treatment of liver metastases from colorectal cancer with hepatic artery occlusion, intraportal 5-fluorouracil infusion, and oral allopurinol. A randomized clinical trial.

• Regional therapy for colorectal liver metastases aimed at prolonging survival has not been tested fully in a randomized trial with untreated control subjects. This study explored the efficacy of temporary hepatic artery occlusion followed by intraportal infusion of 5-fluorouracil (5-FU) and oral allopurinol as biochemical modulators in prolonging the survival of patients with nonresectable liver metastases and no extrahepatic cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Administration

Oral

Adult

Aged

Allopurinol

administration & dosage

Antineoplastic Combined Chemotherapy Protocols

therapeutic use

Colorectal Neoplasms

pathology

Combined Modality Therapy

Constriction

Female

Fluorouracil

administration & dosage

Hepatic Artery

surgery

Humans

Infusions

Intravenous

Liver Neoplasms

blood supply

drug therapy

secondary

therapy

Male

Middle Aged

Portal Vein

Survival Analysis

Treatment Outcome

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)