Clinical use of cerebrospinal fluid biomarkers in Alzheimer's disease.

• The cerebrospinal fluid is a valuable diagnostic fluid that is underutilized. A number of classical neurochemical tests and newer biomarkers of neuropathology may be performed on the cerebrospinal fluid from patients with clinical signs of progressive neurological disease to assist and complement diagnosis. Here, we discuss how they may be employed in the clinical evaluation of patients with memory problems. We argue for their proper application and use, and caution against common misinterpretations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Alzheimer Disease

diagnosis

metabolism

pathology

Amyloid beta-Peptides

cerebrospinal fluid

Biological Markers

cerebrospinal fluid

Blood-Brain Barrier

metabolism

Brain

pathology

Humans

Peptide Fragments

cerebrospinal fluid

tau Proteins

cerebrospinal fluid

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)