Memory B Cells in Mouse Models

• One of the principles behind vaccination, as shown by Edward Jenner in 1796, and host protection is immunological memory, and one of the cells central to this is the antigen-experienced memory B cell that responds rapidly upon re-exposure to the initiating antigen. Classically, memory B cells have been defined as progenies of germinal centre (GC) B cells expressing isotype-switched and substantially mutated B cell receptors (BCRs), that is, membrane-bound antibodies. However, it has become apparent over the last decade that this is not the only pathway to B cell memory. Here, we will discuss memory B cells in mice, as defined by (1) cell surface markers; (2) multiple layers; (3) formation in a T cell-dependent and either GC-dependent or GC-independent manner; (4) formation in a T cell-independent fashion. Lastly, we will touch upon memory B cells in; (5) mouse models of autoimmune diseases.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

helper t-cells

tertiary lymphoid structures

class switch

recombination

germinal center formation

primary immune-response

plasma-cells

somatic hypermutation

antibody-responses

clonal

selection

autoimmune-disease

Animals

Autoimmune Diseases

pathology

B-Lymphocyte Subsets

immunology

pathology

Disease Models

Animal

Gene Expression

immunology

Germinal Center

immunology

pathology

Humans

Immunity

Cellular

Immunoglobulin Isotypes

biosynthesis

Immunologic Memory

Mice

Receptors

Antigen

B-Cell

genetics

immunology

T-Lymphocytes

immunology

pathology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)