Finding the optimal patch test material and test concentration to detect contact allergy to geraniol.

• Background. Geraniol is a commonly used fragrance terpene, and is tested in the baseline series in fragrance mix I. Geraniol is a pro-hapten and a pre-hapten, and sensitizers are formed in the autoxidation and skin metabolism of geraniol. Previous patch testing with air-exposed (oxidized) geraniol has suggested that oxidized geraniol could be a better marker for contact allergy to geraniol than pure geraniol. Objectives. To find the optimal patch test substance and concentration for detecting contact allergy to geraniol. Patients and methods. Six hundred and fifty-five patients were patch tested with pure and oxidized geraniol at 4.0%, 6.0% and 11.0% in petrolatum. Before patch testing, the irritant properties of pure and oxidized geraniol were studied in 27 patients at 2.5%, 5.0%, 10.0% and 20.0% pet. Results. Pure geraniol detected positive reactions in 0.15–1.1% of the patients, and oxidized geraniol detected positive reactions in 0.92–4.6% of the patients. Reactions to pure geraniol in patients not reacting to oxidized geraniol indicated metabolic activation of geraniol. Neither pure nor oxidized geraniol gave significant irritant reactions. Conclusions. Increasing the test concentrations of pure and oxidized geraniol enables the detection of more cases of contact allergy. Oxidized geraniol detects more patients than pure geraniol, but patch testing with only oxidized geraniol does not detect all cases of contact allergy to geraniol.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Nyckelord

Adult

Aged

Aged

80 and over

Allergens

diagnostic use

Cohort Studies

Dermatitis

Allergic Contact

diagnosis

etiology

Dose-Response Relationship

Drug

Female

Humans

Irritants

diagnostic use

Male

Middle Aged

Oxidation-Reduction

Pain Measurement

Patch Tests

methods

Sensitivity and Specificity

Terpenes

adverse effects

immunology

Young Adult

CAS 106-24-1

CAS 106-26-3

CAS 141-27-5

CAS 5392-40-5

skin sensitization

oxidation-products

fragrance terpenes

dermatitis

linalool

hydroperoxides

quantification

identification

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)