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The Relation Betwee...
The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis
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Janssen, P. (författare)
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Harris, M. S. (författare)
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Jones, M. (författare)
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Masaoka, T. (författare)
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Farre, R. (författare)
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- Törnblom, Hans, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,University of Gothenburg Centre for person-centred care (GPCC),Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Van Oudenhove, L. (författare)
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- Simrén, Magnus, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,University of Gothenburg Centre for person-centred care (GPCC)
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Tack, J. (författare)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2013
- 2013
- Engelska.
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Ingår i: American Journal of Gastroenterology. - : Ovid Technologies (Wolters Kluwer Health). - 0002-9270. ; 108:9, s. 1382-1391
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specific correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies. METHODS: The MEDLINE database (1,946 to present) was searched, and only controlled trials or trials with an established effective comparator that compared both SI and GE were included. RESULTS: Studies were identified for metoclopramide (n = 6), domperidone (n = 6), cisapride (n = 14), erythromycin (n = 3), botulinum toxin (n = 2), and levosulpiride (n = 3). Even though most drugs concomitantly improved symptoms and accelerated GE, no study reported a significant correlation between SI and GE. Moreover, a correlation analysis over all studies using meta-regression did not show a significant relationship between SI and GE. Our findings need to be qualified by inconsistencies in study methods, which is a limitation but also suggests that our findings are robust to methodological factors. CONCLUSIONS: In this review, no evidence of a relationship between SI and GE was identified for different drugs used for the treatment of gastroparesis. This finding questions the use of GE measurement to direct drug development for gastroparesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- QUALITY-OF-LIFE
- UPPER GASTROINTESTINAL SYMPTOMS
- PLACEBO-CONTROLLED
- TRIAL
- DOUBLE-BLIND
- FUNCTIONAL DYSPEPSIA
- ORAL CISAPRIDE
- AUTONOMIC
- NEUROPATHY
- THERAPEUTIC EFFICACY
- GLYCEMIC CONTROL
- BOTULINUM-TOXIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Janssen, P.
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Harris, M. S.
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Jones, M.
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Masaoka, T.
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Farre, R.
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Törnblom, Hans, ...
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visa fler...
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Van Oudenhove, L ...
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Simrén, Magnus, ...
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Tack, J.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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American Journal ...
- Av lärosätet
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Göteborgs universitet