Importance of vasoactive intestinal polypeptide in the regulation of burn perfusion.

• Vasoactive intestinal polypeptide is one of the body's most potent vasodilators and has been shown to increase blood flow in a number of tissues. Its effects on postburn skin perfusion and progressive ischemia was investigated in rats exposed to partial- and full-thickness experimental skin burns. Systemic administration of VIP elicited a significant drop in mean arterial blood pressure versus saline (p<0.001) and VIP antiserum (p<0.001) both in burned and nonburned animals. VIP also decreased heart rate versus saline (p<0.05) and anti-VIP (p<0.001) in nonburned and burned animals. In contrast, VIP antiserum significantly increased blood pressure (p<0. 001) and heart rate (p<0.001) versus saline in all the groups. Skin perfusion in normal skin was significantly impaired by VIP infusions as compared to saline (p<0.01) while VIP-antiserum did not differ significantly from saline. Similarly, VIP significantly reduced blood flow versus saline-treatment in partial-thickness (p<0.01) and full-thickness burns (p<0.05) while VIP-antiserum had no significant effect on skin perfusion in any of the burned groups as compared to saline treatment. The present results show that VIP is directly involved in general cardiovascular control but plays a minor role in the maintenance of skin perfusion following a thermal injury as suggested by the lack of effect of VIP-antiserum. In contrast, exogenous administration of VIP significantly and dramatically impaired skin perfusion in normal and burned skin probably by increasing blood flow in organs of higher priority such as the brain and heart and concomitantly inducing a pronounced vasoconstriction in the skin, probably as a result of increased sympathetic effect on peripheral organs in order to maintain blood pressure.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)

Nyckelord

Analysis of Variance

Animals

Blood Pressure

drug effects

Burns

classification

physiopathology

Cardiovascular Physiological Phenomena

drug effects

Confidence Intervals

Heart Rate

drug effects

Immune Sera

pharmacology

Ischemia

physiopathology

Laser-Doppler Flowmetry

Male

Rats

Rats

Sprague-Dawley

Regional Blood Flow

drug effects

Skin

blood supply

injuries

Sodium Chloride

Sympathetic Nervous System

drug effects

Vasoactive Intestinal Peptide

antagonists & inhibitors

pharmacology

Vasodilator Agents

antagonists & inhibitors

pharmacology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)