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Dose-dependent asso...
Dose-dependent association of smoking and bronchial hyperresponsiveness
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Juusela, M. (författare)
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Pallasaho, P. (författare)
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- Rönmark, Eva, 1953 (författare)
- Umeå universitet,Yrkes- och miljömedicin,Sunderby Central Hospital of Norrbotten, Luleå
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Sarna, S. (författare)
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Sovijarvi, A. (författare)
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- Lundbäck, Bo, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre
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(creator_code:org_t)
- 2013-05-30
- 2013
- Engelska.
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 42:6, s. 1503-1512
- Relaterad länk:
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https://erj.ersjourn...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Our aim was to study the association of smoking habits and environmental tobacco smoke (ETS) exposure with bronchial hyperresponsiveness (BHR). A random sample of 292 adults was examined using a structured interview, spirometry, skin prick tests, exhaled nitric oxide fraction (FeNO) and bronchial histamine challenge. A large majority of subjects with BHR were smokers or ex-smokers. Starting to smoke before 20 years of age was significantly associated with BHR, as was current smoking, quantity of smoking and ETS exposure. The severity of BHR increased significantly with increasing pack-years of exposure (p<0.001). Current smokers with decreased lung function were at a particularly high risk of BHR. Impaired forced expiratory volume in 1 s and mean maximal expiratory flow were independent determinants for more severe BHR, regardless of age. In multivariate analysis, smoking remained an independent determinant for BHR after adjustment for impaired lung function and other covariates: >= 15 pack-years yielded an odds ratio of 3.00 (95% CI 1.33-6.76) for BHR. The association between BHR and FeNO was dependent on smoking habits. The results indicate that smoking is a significant risk factor for BHR, with a dose-dependent pattern, and that the severity of BHR increases with pack-years. The findings strongly suggest assessment of smoking habits in subjects with BHR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- RESPIRATORY HEALTH SURVEY
- EXHALED NITRIC-OXIDE
- LUNG-FUNCTION
- AIRWAY
- HYPERRESPONSIVENESS
- COMMON ALLERGENS
- ASTHMA
- POPULATION
- RESPONSIVENESS
- CESSATION
- HELSINKI
- IDE NB
- 1979
- BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- V8
- P193
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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