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TMPRSS2-ERG Express...
TMPRSS2-ERG Expression Predicts Prostate Cancer Survival and Associates with Stromal Biomarkers
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- Hägglöf, Christina (författare)
- Umeå universitet,Patologi
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- Hammarsten, Peter (författare)
- Umeå universitet,Patologi
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- Strömvall, Kerstin (författare)
- Umeå universitet,Patologi
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- Egevad, L. (författare)
- Karolinska Institutet
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- Josefsson, Andreas, 1979 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för urologi,Institute of Clinical Sciences, Department of Urology
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- Stattin, Pär (författare)
- Umeå universitet,Uppsala universitet,Urologkirurgi,Urologi och andrologi
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Granfors, T. (författare)
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- Bergh, Anders (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2014-02-05
- 2014
- Engelska.
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 9:2
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://umu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The TMPRSS2-ERG gene fusion is found in approximately half of all prostate cancers. The functional and prognostic significance of TMPRSS2-ERG is, however, not fully understood. Based on a historical watchful waiting cohort, an association between TMPRSS2-ERG, evaluated as positive immune staining, and shorter survival of prostate cancer patients was identified. Expression of ERG was also associated with clinical markers such as advanced tumor stage, high Gleason score, presence of metastasis and prognostic tumor cell markers such as high Ki67, pEGFR and pAkt. Novel associations between TMPRSS2-ERG and alterations in the tumor stroma, for example, increased vascular density, hyaluronan and PDGFR beta and decreased Caveolin-1, all known to be associated with an aggressive disease, were found. The present study suggests that the TMPRSS2-ERG fusion gene is associated with a more aggressive prostate cancer phenotype, supported by changes in the tumor stroma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- TRANSCRIPTION FACTOR
- ERG EXPRESSION
- GLEASON SCORE
- GENE FUSIONS
- TUMOR-GROWTH
- REARRANGEMENT
- FIBROBLASTS
- PROGRESSION
- CELLS
- STRATIFICATION
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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