Osteoporosis in chronic inflammatory disease: The role of malnutrition

• Osteoporosis is a metabolic bone disorder affecting million of people worldwide. Increased understanding of bone disease has led to a greater recognition of factors affecting bones, and consequently many secondary causes of osteoporosis were demonstrated. In this study, we aim to explore possible causes of bone loss and fractures in subjects affected by chronic inflammatory disease and to suggest new targets for intervention. In fact several studies, evaluated to perform this study, suggest that the patients with chronic inflammatory disease could be at high risk for fractures due to bone loss as consequence of malnutrition, caused by inflammation and hormonal change. Consequently, some actions could derive from the considerations of these mechanisms: a change in actual approach of chronic patients, that may include the investigation on the possible presence of osteoporosis, as well as further research on this topic to find a better therapy to prevent osteoporosis considering all the mechanisms described. © 2012 Springer Science+Business Media New York.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

Anorexia

Cachexia

Inflammation

Malnutrition

Osteoporosis

adiponectin

calcium

cytokine

leptin

magnesium

vitamin D

calcium homeostasis

chronic inflammation

cytokine production

fracture

fragility fracture

hormone action

human

nonhuman

osteolysis

priority journal

review

risk factor

risk reduction

Aging

Bone and Bones

Chronic Disease

Cytokines

Female

Humans

Male

Osteoporosis

Postmenopausal

Osteoporotic Fractures

Publication and Content Type

ref (subject category)

art (subject category)