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Actin Controls the ...
Actin Controls the Vesicular Fraction of Dopamine Released During Extended Kiss and Run Exocytosis
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- Trouillon, Raphaël, 1982 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
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- Ewing, Andrew G, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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(creator_code:org_t)
- 2014-01-21
- 2014
- Engelska.
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Ingår i: Acs Chemical Biology. - : American Chemical Society (ACS). - 1554-8929 .- 1554-8937. ; 9:3, s. 812-820
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Abstract
Ämnesord
Stäng
- The effect of latrunculin A, an inhibitor of actin cross-linking, on exocytosis in PC12 cells was investigated with single cell amperometry. This analysis strongly suggests that the actin cytoskeleton might be involved in regulating exocytosis, especially by mediating the constriction of the pore. In an extended kiss-and-run release mode, actin could actually control the fraction of neurotransmitters released by the vesicle. This scaffold appears to contribute, with the lipid membrane and the protein machinery, to the closing dynamics of the pore, in competition with other forces mediating the opening of the exocytotic channel.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- SINGLE VESICLE RELEASE
- DENSE-CORE VESICLES
- FUSION PORE
- CHROMAFFIN
- CELLS
- QUANTAL SIZE
- NEUROTRANSMITTER RELEASE
- AMPEROMETRIC DETECTION
- MICROELECTRODE ARRAYS
- REGULATED EXOCYTOSIS
- CHEMICAL-ANALYSIS
- MICROELECTRODE ARRAYS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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