Platelet proteins as autoantibody targets in idiopathic thrombocytopenic purpura.

• Idiopathic thrombocytopenic purpura (ITP), caused by autoantibodies directed against certain platelet antigens, is the most common entity of the immune thrombocytopenias. ITP is an acquired disorder and can affect both children and adults. However, the clinical syndromes of ITP are distinct between children and adults. Childhood (acute) ITP characteristically is acute in onset, occurs within 1-2 weeks of an infection, usually of viral origin, resolves spontaneously within 6 months. Adult (chronic) ITP has an insidious onset and rarely resolves spontaneously. Over the last decade considerable new information has accumulated as to the pathophysiological mechanisms of immune thrombocytopenias. In addition, most of the knowledge on this disorder has been obtained from studies of adult patients with chronic ITP. The present work gives an updated overview of the platelet autoantigens and the molecular immunological reactions in ITP.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Acute Disease

Adult

Antigens

CD31

Antigens

CD36

Autoantibodies

immunology

Blood Platelets

immunology

Child

Chronic Disease

Humans

Immunity

Cellular

immunology

Immunoglobulin G

immunology

Platelet Glycoprotein GPIIb-IIIa Complex

Platelet Glycoprotein GPIb-IX Complex

Platelet Membrane Glycoproteins

Purpura

Thrombocytopenic

Idiopathic

immunology

physiopathology

virology

Receptors

Cell Surface

Tropomyosin

immunology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)