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The effect of an is...
The effect of an isoprenaline infusion on the splenic blood flow and intrasplenic platelet kinetics.
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- Wadenvik, Hans, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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- Kutti, Jack (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
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(creator_code:org_t)
- 1987
- 1987
- Engelska.
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Ingår i: European journal of haematology. - 0902-4441. ; 39:1, s. 7-13
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The effect of a constant isoprenaline infusion on the venous platelet count, splenic blood flow and intrasplenic platelet kinetics was investigated in 6 healthy male volunteers. The study was carried out using autologous 111In-labelled platelets and dynamic gamma camera imaging of the initial distribution of radiolabelled platelets between blood and splenic platelet pool. The isoprenaline infusions were administered i.v. over 30 min in a dose of 0.03 micrograms/kg/min. These infusions significantly increased the splenic blood flow and the size of the exchangeable splenic platelet pool. Concomitantly, there was a decrease of labelled as well as unlabelled platelets in the peripheral blood. The intrasplenic platelet transit time was not affected. Before start of infusion, the splenic blood flow was 6.1 +/- 2.9 (SD) % of total blood volume/min and the splenic platelet pool size 34 +/- 9 (SD) %. During infusion the corresponding values were 8.7 +/- 3.9 (SD) and 41 +/- 11 (SD), respectively. It is concluded that an i.v. infusion of isoprenaline enhances splenic pooling of platelets as a result of an increase in splenic blood flow.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Adult
- Blood Platelets
- cytology
- physiology
- Humans
- Infusions
- Intravenous
- Isoproterenol
- pharmacology
- Kinetics
- Male
- Platelet Count
- Regional Blood Flow
- drug effects
- Spleen
- blood supply
- radionuclide imaging
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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