Apolipoprotein B and Apolipopotein A-I in Vascular Risk Prediction - A Review

• The concentration of low-density lipoprotein cholesterol has long been generally accepted as one of the strongest, independent risk factors for the development of cardiovascular disease. However, an increasing number of studies suggest that the ratio of apolipoprotein B (apoB) to apolipoprotein A-I (apoA-I) is a better risk predictor. In the present review, we focus on apoB and apoA-I as factors in predicting vascular risk in epidemiological studies only, and not in studies involving pharmaceutical intervention. The majority of studies in the present review show that apoB and the apoB/apoA-I ratio are independently and more strongly associated with vascular risk across varying age-groups and geographic regions than are conventional lipids, lipoproteins and lipid ratios.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Samhällsfarmaci och klinisk farmaci (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Social and Clinical Pharmacy (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

Apolipoprotein B

apoB/apoA-I ratio

intima-media thickness

plaque

myocardial infarction

stroke

CORONARY-HEART-DISEASE

DENSITY LIPOPROTEIN CHOLESTEROL

ACUTE

MYOCARDIAL-INFARCTION

FEMORAL-ARTERY PLAQUES

CHRONIC KIDNEY-DISEASE

MIDDLE-AGED MEN

CARDIOVASCULAR RISK

METABOLIC SYNDROME

LDL

CHOLESTEROL

FOLLOW-UP

Pharmacology & Pharmacy

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