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Microbial Modulatio...
Microbial Modulation of Insulin Sensitivity
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- Khan, M. T. (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Nieuwdorp, Max (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Bäckhed, Fredrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Cell Metabolism. - : Elsevier BV. - 1550-4131. ; 20:5, s. 753-760
- Relaterad länk:
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The gut microbiota has emerged as an integral factor that impacts host metabolism and has been suggested to play a vital role in metabolic diseases such as obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. In humans, cross-sectional studies have identified microbiota profiles associated with metabolic diseases, whereas causation mainly has been demonstrated in animal models. Recent studies involving microbiota-based interventions in humans, or transfer of disease-associated microbiota into germ-free mice, underscore that an altered microbiota may directly modulate host metabolism in humans. However, it will be essential to determine whether an altered gut microbiota precedes development of insulin resistance and diabetes and to identify the underlying molecular mechanisms. Increased mechanistic insights of how the microbiota modulates metabolic disease in humans may pave the way for identification of innovative microbiota-based diagnostics and/or therapeutics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- DIET-INDUCED OBESITY
- Y GASTRIC BYPASS
- BILE-ACID METABOLISM
- GERM-FREE
- MICE
- GUT MICROBIOTA
- BARIATRIC SURGERY
- ADIPOSE-TISSUE
- GLUCOSE-HOMEOSTASIS
- SLEEVE GASTRECTOMY
- ENERGY-EXPENDITURE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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