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The effect of exerc...
The effect of exercise on angiogenic factors in the healthy mouse heart: A short report
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- Karazisi, Christina (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Onerup, Aron, 1983 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Larsson, Pia, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Carlsson, Lena M S, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Börjesson, Mats, 1965 (författare)
- Gymnastik- och idrottshögskolan,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Åstrandlaboratoriet
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- DuttaRoy, Smita, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Dutta Roy, Smita (författare)
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(creator_code:org_t)
- Pulsus Group Inc. 2014
- 2014
- Engelska.
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Ingår i: Experimental and Clinical Cardiology. - : Pulsus Group Inc.. - 1205-6626. ; 20:1, s. 2332-2341
- Relaterad länk:
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http://cardiologyaca...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Exercise increases blood levels of crucial angiogenic factors and endothelial progenitor cells (EPCs). Hypoxia inducible factor-1 (HIF-1a) and vascular endothelial growth factor (VEGF) are also increased in skeletal muscle in response to exercise. In the healthy heart, voluntary exercise is not expected to cause local hypoxia. We studied how voluntary exercise affects cardiac expression of HIF-1a, VEGF and stromal derived factor-1 (SDF-1), as well as EPC levels in heart and skeletal muscle. Method: Thirty-two NMRI mice were randomized to exercise in running wheels (EX) or regular activity (SED). HIF-1a, VEGF and SDF-1 mRNA levels were analyzed by reverse transcription polymerase chain reaction (RT-PCR) and EPC levels in heart and hind limb were quantified by FACS after 7 and 14 days. Results: There was no significant difference in cardiac expression of HIF-1a, VEGF or SDF-1 between EX and SED. Cardiac EPC levels were not affected by exercise, while skeletal EPC level was more than doubled. Conclusion: Voluntary exercise does not seem to induce cardiac hypoxia or stimulate the angiogenic system. In the healthy normoxic heart, there is a limited need of supporting blood supply, which might explain these findings.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- Endothelial progenitor cells
- Exercise
- Heart
- angiogenic factor
- hypoxia inducible factor 1alpha
- messenger RNA
- stromal cell derived factor 1
- vasculotropin
- angiogenesis
- animal experiment
- animal tissue
- article
- cardiovascular effect
- cardiovascular risk
- controlled study
- coronary artery blood flow
- endothelial progenitor cell
- female
- fluorescence activated cell sorting
- heart muscle
- hindlimb
- hypoxia
- mouse
- muscle growth
- NMRI mouse
- nonhuman
- protein expression
- reverse transcription polymerase chain reaction
- sedentary lifestyle
- sitting
- treadmill exercise
- Medicin/Teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Karazisi, Christ ...
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Onerup, Aron, 19 ...
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Larsson, Pia, 19 ...
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Carlsson, Lena M ...
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Börjesson, Mats, ...
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DuttaRoy, Smita, ...
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visa fler...
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Dutta Roy, Smita
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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- Av lärosätet
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Göteborgs universitet
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Gymnastik- och idrottshögskolan