New puberty growth model for estimation of age for peak height velocity ompared with a manual method.

• Background: There is a lack of methods describing pubertal growth in a computerized way. Objective and hypotheses: To compare a mathematical model, describing pubertal growth, for age at start P5%, mid P50% and end P95% of pubertal growth and total curve peak height velocity (TPHV) to compare with manually identified PHV. Methods: From a new growth model (QEPs Quadratic Exponential Puberty stop) we used the P(uberty) function for estimating PO (5% of P(AUC), mid puberty as P50% and PE (95% of P(AUC)). The calculated PHV from total growth curve (TPHV) was compared with the manually identified PHV (against a ICP based grid) . The Swedish growth reference, born 1974 (n=3655 of which 2622) was selected. Results: For the 1320 boys mean (SD) of ageP50% was 13.82 (0.96), ageTPHV 13.67 (0.97) and age at PHV 13.85 (1.00). For the 1302 girls mean (SD) of ageP50% was 12.08 (0.97), ageTPH 11.81 (0.99) and age at PHV 11.93 (0.95). PO, as P5% for boys was 11.77 (1.00) and for girls 9.80 (1.04). PE, as P95% for boys was 16.16 (0.99) and for girls 14.70 (0.97) giving a mean duration for boys of 4.8 years and 4.9 years for girls. The mean age difference between PHV and TPHV was for boys 0.18 (0.38) and for girls 0.11 (0.48). The mean difference between PHV and P50% was for boys 0.03 (0.38) and for girls -0.15 (0.48). Conclusions: This new puberty growth model gives computerized information of start, mid and end of pubertal growth as well as the age at TPHV. This makes possible a better evaluation of influence of hormones, disease and environment on timing of amount of pubertal growth.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

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