The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease

• It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of A beta 42 and normal levels of CSF neurofilament light protein and sAPP alpha and sAPP beta, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

Alzheimer's disease

HIV

CSF biomarkers

NEUROFILAMENT PROTEIN NFL

CENTRAL-NERVOUS-SYSTEM

ANTIRETROVIRAL

THERAPY

FRONTOTEMPORAL DEMENTIA

UNINFECTED INDIVIDUALS

LIFE

EXPECTANCY

RISK-FACTORS

TAU-PROTEIN

CSF

COHORT

Infectious Diseases

ATES OF AMERICA

V83

P4913

ARTHUR JC

1993

NEUROLOGY

V43

P2245

Alzheimer's disease

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