Sökning: id:"swepub:oai:gup.ub.gu.se/220196" >
Characterising temp...
Characterising temporal trends in asymptomatic Plasmodium infections and transporter polymorphisms during transition from high to low transmission in Zanzibar, 2005-2013
-
- Morris, U. (författare)
- Karolinska Institutet
-
Xu, W. P. (författare)
-
Msellem, M. I. (författare)
-
visa fler...
-
Schwartz, A. (författare)
-
- Abass, A. (författare)
- Karolinska Institutet
-
Shakely, D. (författare)
-
Cook, J. (författare)
-
Bhattarai, A. (författare)
-
- Petzold, Max, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
-
Greenhouse, B. (författare)
-
Ali, A. S. (författare)
-
Bjorkman, A. (författare)
-
- Froberg, G. (författare)
- Karolinska Institutet
-
- Mårtensson, Andreas (författare)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- Engelska.
-
Ingår i: Infection Genetics and Evolution. - : Elsevier BV. - 1567-1348 .- 1567-7257. ; 33, s. 110-117
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Improved understanding of the asymptomatic malaria parasite reservoir is a prerequisite to pursue malaria elimination efforts. We therefore characterised temporal trends and transporter polymorphisms in asymptomatic Plasmodium infections during the transition from high to low transmission in Zanzibar. Methods: Healthy individuals participating in cross-sectional surveys conducted 2005-2013 were screened for asymptomatic malaria by PCR. Complexity/diversity of infection and transporter polymorphisms were assessed in Plasmodium falciparum positive samples. Symptomatic samples were included for comparison of polymorphisms in 2013. Results: PCR-determined parasite prevalence declined from 21.1% (CI95% 17.4-24.9) to 2.3% (CI95% 1.7-2.9) from 2005 to 2013. P. falciparum remained the predominant species; prevalence was highest in children and young adults aged 5-25 years. Parasite densities and complexity of infection, but not population genetic diversity of P. falciparum, decreased from 2005-2009. pfcrt 761 (99.2-64.7%, p < 0.001) and pfmdr1 86Y frequencies (89.4-66.7%, p = 0.03) decreased over time. Pfmdr1 (a.a.86,184,1246) YYY and YYD haplotypes were more frequent in asymptomatic than symptomatic infections in 2013 (p < 0.001). Conclusions: There is a declining, albeit persistent, reservoir of parasites present at low-densities in asymptomatic individuals in Zanzibar. This study revealed important characteristics of the remaining parasite population, including intriguing temporal trends in molecular markers associated with antimalarial resistance, which need to be further investigated. (C) 2015 Elsevier B.V. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Asymptomatic
- Plasmodium
- Low transmission
- Molecular surveillance
- Antimalarial drug resistance
- POLYMERASE-CHAIN-REACTION
- FALCIPARUM DRUG-RESISTANCE
- MALARIA PARASITE
- CARRIAGE
- RAPID DIAGNOSTIC-TESTS
- MOLECULAR SURVEILLANCE
- IN-VITRO
- ARTEMETHER-LUMEFANTRINE
- ARTESUNATE-AMODIAQUINE
- COMBINATION THERAPY
- PFMDR1 GENES
- Infectious Diseases
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Morris, U.
-
Xu, W. P.
-
Msellem, M. I.
-
Schwartz, A.
-
Abass, A.
-
Shakely, D.
-
visa fler...
-
Cook, J.
-
Bhattarai, A.
-
Petzold, Max, 19 ...
-
Greenhouse, B.
-
Ali, A. S.
-
Bjorkman, A.
-
Froberg, G.
-
Mårtensson, Andr ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Infektionsmedici ...
- Artiklar i publikationen
-
Infection Geneti ...
-
Infection, genet ...
- Av lärosätet
-
Göteborgs universitet
-
Karolinska Institutet
-
Uppsala universitet