Absolute Asymmetric Synthesis: Viedma Ripening of Co(bpy)(3) (2+) and Solvent-Free Oxidation to Co(bpy)(3) (3+)

• Syntheses of [Co(bpy)(3)](2+) yield racemic solutions because the - and -enantiomers are stereochemically labile. However, crystallization and attrition-enhanced deracemization can give homochiral crystal batches of either handedness in quantitative yield. Subsequently, solvent-free oxidation with bromine vapour fixes the chirality because [Co(bipy)(3)](3+) does not enantiomerize in solution at ambient temperature. This combination of Viedma ripening and the labile/inert Co-II/Co-III couple constitutes a convenient method of absolute asymmetric synthesis.

Ämnesord

NATURVETENSKAP  -- Kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences (hsv//eng)

Nyckelord

asymmetric synthesis

circular dichroism

cobalt

deracemization

structure elucidation

ATTRITION-ENHANCED DERACEMIZATION

CHIRAL-SYMMETRY-BREAKING

SOLID-STATE

CIRCULAR-DICHROISM

METAL-COMPLEXES

RESOLUTION

CRYSTALLIZATION

AUTOCATALYSIS

REAGENTS

1

10-PHENANTHROLINE

Chemistry

Multidisciplinary

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