Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis

• Herpes simplex encephalitis (HSE) is characterized by a pronounced inflammatory activity in the central nervous system (CNS). Here, we investigated the acute and prolonged complement system activity in HSE patients, by using enzyme-linked immunosorbent assays (ELISAs) for numerous complement components (C). We found increased cerebrospinal fluid concentrations of C3a, C3b, C5 and C5a in HSE patients compared with healthy controls. C3a and C5a concentrations remained increased also compared with patient controls. Our results conclude that the complement system is activated in CNS during HSE in the acute phase, and interestingly also in later stages supporting previous reports of prolonged inflammation. (C) 2016 Elsevier B.V. All rights reserved.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Complement activation

Herpes simplex virus type 1

Herpes simplex encephalitis

Central nervous system infection

Anaphylatoxins

glycoprotein-c

virus

brain

c3a

pathogenesis

multicenter

meningitis

infections

acyclovir

diagnosis

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)