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First Morning Voide...
First Morning Voided Urinary Gonadotropin Measurements as an Alternative to the GnRH Test
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Demir, A. (författare)
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Voutilainen, R. (författare)
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Stenman, U. H. (författare)
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Dunkel, L. (författare)
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- Albertsson-Wikland, Kerstin, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Norjavaara, Ensio, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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(creator_code:org_t)
- 2016-03-25
- 2016
- Engelska.
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Ingår i: Hormone Research in Paediatrics. - : S. Karger AG. - 1663-2818 .- 1663-2826. ; 85:5, s. 301-308
- Relaterad länk:
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https://www.karger.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims: We studied whether first morning voided ( FMV) urinary gonadotropin measurements could be used as a noninvasive alternative to the GnRH test in the assessment of the hypothalamic-pituitary-gonadal function in children. Methods: In a single-center study, we compared FMV urinary gonadotropin concentrations with basal and GnRH-stimulated serum gonadotropin levels in 274 children and adolescents (78 girls, 196 boys) aged 5-17 years referred for growth and pubertal disorders. The concordance between FMV urinary gonadotropin concentrations and GnRH test results was assessed. Results: FMV urinary LH (U-LH), urinary FSH (U-FSH) and their ratios correlated well with the corresponding basal and GnRH-stimulated serum parameters (r = 0.66, p < 0.001). Receiver operating characteristic curve analyses using urinary and serum LH and FSH concentrations showed that FMV U-LH and U-LH/U-FSH performed equally well as the GnRH test in the differentiation of early puberty (Tanner stage 2) from prepuberty (Tanner stage 1) (area under the curve 0.768-0.890 vs. 0.712-0.858). FMV U-LH and U-LH/UFSH performed equally well as basal serum LH in predicting a pubertal GnRH test result (area under the curve 0.90-0.93). Conclusion: FMV U-LH determination can be used for the evaluation of pubertal development and its disorders, reducing the need for invasive GnRH stimulation tests. (C) 2016 S. Karger AG, Basel
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Luteinizing hormone
- Follicle-stimulating hormone
- Gonadotropin-releasing hormone test
- Hypothalamic-pituitary-gonadal function
- Pubertal disorders
- central precocious puberty
- hormone-releasing hormone
- follicle-stimulating-hormone
- luteinizing-hormone
- normal-children
- immunofluorometric assays
- lh-rh
- serum
- patterns
- increase
- mir a
- 1995
- journal of clinical endocrinology & metabolism
- v80
- p1457
- mir a
- 1994
- pediatric research
- v36
- p221
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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