Dramatis Personae in β-Cell Mass Regulation: Enter SerpinB1

• How is β-cell mass adjusted to changes in the functional insulin requirements? The answer to this question is central to the understanding of the causes and (potentially) the therapy of type 2 diabetes. In this issue of Cell Metabolism, El Ouaamari et al. (2016) report that increased production of the protease inhibitor SerpinB1 in the liver links insulin resistance to stimulation of β-cell proliferation. © 2016 Elsevier Inc.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

blood sampling; cell proliferation; genetic variability; glucose homeostasis; human; hyperglycemia; in vitro study; insulin release; insulin resistance; insulin sensitivity; knockout mouse; liver cell; neutrophil; non insulin dependent diabetes mellitus; nonhuman; obesity; white adipose tissue

Publikations- och innehållstyp

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