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Associations betwee...
Associations between Performance onanAbbreviated CogState Battery, OtherMeasures of Cognitive Function, andBiomarkers in People at Risk forAlzheimer's Disease.
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Racine, Annie M (författare)
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Clark, Lindsay R (författare)
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Berman, Sara E (författare)
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Koscik, Rebecca L (författare)
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Mueller, Kimberly D (författare)
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Norton, Derek (författare)
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Nicholas, Christopher R (författare)
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Jedynak, Bruno (författare)
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Bilgel, Murat (författare)
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Carlsson, Cynthia M (författare)
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Christian, Bradley T (författare)
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Asthana, Sanjay (författare)
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Johnson, Sterling C (författare)
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 54:4, s. 1395-1408
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer's disease(AD). In 469 late middle-aged participants from the Wisconsin Registry for Alzheimer's Prevention(mean age 63.8±7 years at testing; 67% female; 39% APOE4+), we examined relationships between a CogState abbreviated battery(CAB) of seven tests and demographic characteristics; traditional paper-based neuropsychological tests as well as a composite cognitive impairment index; cognitive impairment status(determined by consensus review); and biomarkers for amyloid and tau(CSF phosphorylated-tau/Aβ42 and global PET-PiB burden) and neural injury(CSF neurofilament light protein). CSF and PET-PiB were collected in n=71 and n=91 participants, respectively, approximately four years prior to CAB testing. For comparison, we examined three traditional tests of delayed memory in parallel. Similar to studies in older samples, the CAB was less influenced by demographic factors than traditional tests. CAB tests were generally correlated with most paper-based cognitive tests examined and mapped onto the same cognitive domains. Greater composite cognitive impairment index was associated with worse performance on all CAB tests. Cognitively impaired participants performed significantly worse compared to normal controls on all but one CAB test. Poorer One Card Learning test performance was associated with higher levels of CSF phosphorylated-tau/Aβ42. These results support the use of the CogState battery as measures of early cognitive impairment in studies of people at risk for AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Amyloid
- biomarkers
- cerebrospinal fluid
- cognitive impairment
- CogState
- computerized cognitive testing
- neural injury
- preclinical Alzheimer’s disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Racine, Annie M
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Clark, Lindsay R
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Berman, Sara E
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Koscik, Rebecca ...
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Mueller, Kimberl ...
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Norton, Derek
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visa fler...
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Nicholas, Christ ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Jedynak, Bruno
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Bilgel, Murat
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Carlsson, Cynthi ...
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Christian, Bradl ...
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Asthana, Sanjay
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Johnson, Sterlin ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Journal of Alzhe ...
- Av lärosätet
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Göteborgs universitet