Salivary acinic cell carcinoma: reappraisal and update

• Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Acinic cell carcinoma

Pathology

Salivary glands

Therapy

Prognosis

Mammary analog secretory

analog secretory carcinoma

intercalated duct differentiation

fine-needle-aspiration

parotid-gland

ultrastructural morphology

mucoepidermoid carcinoma

recent trends

tumors

adenocarcinoma

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