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Comparative sensiti...
Comparative sensitizing potencies of fragrances, preservatives, and hair dyes
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- Liden, C. (författare)
- Karolinska Institutet
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Yazar, K. (författare)
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Johansen, J. D. (författare)
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- Karlberg, Ann-Therese, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Uter, W. (författare)
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White, I. R. (författare)
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(creator_code:org_t)
- 2016-10-05
- 2016
- Engelska.
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 75:5, s. 265-275
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The local lymph node assay (LLNA) is used for assessing sensitizing potential in hazard identification and risk assessment for regulatory purposes. Sensitizing potency on the basis of the LLNA is categorized into extreme (EC3 value of <= 0.2%), strong (>0.2% to <= 2%), and moderate (>2%). To compare the sensitizing potencies of fragrance substances, preservatives, and hair dye substances, which are skin sensitizers that frequently come into contact with the skin of consumers and workers, LLNA results and EC3 values for 72 fragrance substances, 25 preservatives and 107 hair dye substances were obtained from two published compilations of LLNA data and opinions by the Scientific Committee on Consumer Safety and its predecessors. The median EC3 values of fragrances (n=61), preservatives (n=19) and hair dyes (n=59) were 5.9%, 0.9%, and 1.3%, respectively. The majority of sensitizing preservatives and hair dyes are thus strong or extreme sensitizers (EC3 value of <= 2%), and fragrances are mostly moderate sensitizers. Although fragrances are typically moderate sensitizers, they are among the most frequent causes of contact allergy. This indicates that factors other than potency need to be addressed more rigorously in risk assessment and risk management.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- EC3 value
- fragrances
- hair dyes
- hazard
- preservatives
- risk assessment
- Scientific Committee on
- LYMPH-NODE ASSAY
- ALLERGIC CONTACT-DERMATITIS
- 5 EUROPEAN COUNTRIES
- SKIN SENSITIZATION
- OXIDATION-PRODUCTS
- COUPLED EXPOSURE
- AIR EXPOSURE
- METHYLISOTHIAZOLINONE
- QUANTIFICATION
- IDENTIFICATION
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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