Cohort study of growth patterns by gestational age in preterm infants developing morbidity.

• To examine differences in growth patterns in preterm infants developing major morbidities including retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), necrotising enterocolitis (NEC) and intraventricular haemorrhage (IVH).Cohort study of 2521 infants born at a gestational age (GA) of 23-30weeks from 11 level III neonatal intensive care units in USA and Canada, and 3 Swedish population-based cohorts.Birth weight and postnatal weight gain were examined relative to birth GA and ROP, BPD, NEC and IVH development.Among infants with a birth GA of 25-30weeks, birth weight SD score and postnatal weight were lower in those developing ROP and BPD. Infants developing ROP showed lower growth rates during postnatal weeks 7-9 in the 23-24weeks GA group, during weeks 4-6 in the 25-26weeks GA group and during weeks 1-5 in the 27-30weeks GA group. Infants with BPD born at 27-30weeks GA showed lower growth rates during postnatal weeks 3-5. Infants with NEC had lower growth rates after postnatal week 6 in all GA groups, with no significant differences in birth weight SD score. IVH was not associated with prenatal or postnatal growth.In this cohort study of extremely preterm infants, we found that the postnatal growth pattern was associated with morbidities such as ROP, BPD and NEC as well as with gestational age at birth.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmänmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- General Practice (hsv//eng)

Nyckelord

Retinopathy of prematurity

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