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Amniotic fluid cath...
Amniotic fluid cathepsin-G in pregnancies complicated by the preterm prelabor rupture of membranes.
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Musilova, Ivana (författare)
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Andrys, Ctirad (författare)
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Drahosova, Marcela (författare)
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Soucek, Ondrej (författare)
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Pliskova, Lenka (författare)
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Stepan, Martin (författare)
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Bestvina, Tomas (författare)
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Maly, Jan (författare)
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- Jacobsson, Bo, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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Kacerovsky, Marian (författare)
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(creator_code:org_t)
- 2016-10-09
- 2017
- Engelska.
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Ingår i: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. - : Informa UK Limited. - 1476-7058 .- 1476-4954. ; 30:17, s. 2097-2104
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- The aim of this study was to evaluate the amniotic fluid cathepsin-G concentrations in women with preterm prelabor rupture of membranes (PPROM) based on the presence of the microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI).A total of 154 women with singleton pregnancies complicated by PPROM were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis. Amniotic fluid cathepsin-G concentrations were assessed by ELISA. MIAC was determined using a non-cultivation approach. IAI was defined as an amniotic fluid bedside interleukin-6 concentration≥745pg/mL.Women with MIAC had higher amniotic fluid cathepsin-G concentrations than women without MIAC (with MIAC: median 82.7ng/mL, versus without MIAC: median 64.7ng/mL; p=0.0003). Women with IAI had higher amniotic fluid cathepsin-G concentrations than women without this complication (with IAI: median 103.0ng/mL, versus without IAI: median 66.2ng/mL; p<0.0001). Women with microbial-associated (with both MIAC and IAI) IAI and sterile (IAI without MIAC) IAI had higher amniotic fluid cathepsin-G concentrations than women with colonization (MIAC without IAI) and women without both MIAC and IAI (p<0.0001).The presence of either microbial-associated or sterile IAI was associated with increased amniotic fluid cathepsin-G concentrations in pregnancies complicated by PPROM. Amniotic fluid cathepsin-G appears to be a potential marker of IAI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Musilova, Ivana
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Andrys, Ctirad
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Drahosova, Marce ...
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Soucek, Ondrej
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Pliskova, Lenka
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Stepan, Martin
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visa fler...
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Bestvina, Tomas
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Maly, Jan
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Jacobsson, Bo, 1 ...
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Kacerovsky, Mari ...
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- MEDICIN OCH HÄLSOVETENSKAP
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Göteborgs universitet