Noggin is required for induction of the hair follicle growth phase in postnatal skin.

• During postnatal development, the hair follicle (HF) shows cyclic activity with periods of relative resting, active growth (anagen), and regression. We demonstrate that similar to the HF induction in embryonic skin, initiation of a new hair growth phase in postnatal skin requires neutralization of the inhibitory activity of bone morphogenetic protein 4 (BMP4) by the BMP antagonist noggin. In the resting HF, BMP4 mRNA predominates over noggin in the epithelium and mesenchyme, and the BMP receptor IA is prominently expressed in the follicular germ. Anagen development is accompanied by down-regulation of the BMP4 and increased noggin mRNA in the HF. Furthermore, administration of noggin protein induces new hair growth phase in postnatal telogen skin in vivo. In contrast, BMP4 induces selective arrest of anagen development in the non-tylotrich (secondary) HF. As a hair growth inducer, noggin increases Shh mRNA in the HF whereas BMP4 down-regulates Shh. This suggests that modulation of BMP4 signaling by noggin is essential for hair growth phase induction in postnatal skin and that the hair growth-inducing effect of noggin is mediated, at least in part, by Shh.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Nyckelord

Animals

Bone Morphogenetic Protein 4

Bone Morphogenetic Protein Receptors

Type I

Bone Morphogenetic Proteins

biosynthesis

genetics

pharmacology

Carrier Proteins

Down-Regulation

Female

Hair Follicle

anatomy & histology

drug effects

growth & development

Hedgehog Proteins

Mice

Mice

Inbred C57BL

Models

Biological

Protein Biosynthesis

Protein-Serine-Threonine Kinases

biosynthesis

genetics

Proteins

genetics

pharmacology

RNA

Messenger

biosynthesis

Receptors

Growth Factor

biosynthesis

genetics

Trans-Activators

biosynthesis

genetics

Up-Regulation

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)