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Identification of S...
Identification of Shared and Unique Serum Lipid Profiles in Diabetes Mellitus and Myocardial Infarction
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Kjellqvist, S. (author)
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Klose, C. (author)
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Surma, M. A. (author)
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Hindy, G. (author)
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Mollet, I. G. (author)
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Johansson, A. (author)
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Chavaux, P. (author)
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- Gottfries, Johan, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Simons, K. (author)
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Melander, O. (author)
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Fernandez, C. (author)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2016
- 2016
- English.
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In: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 5:12
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https://doi.org/10.1...
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Abstract
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- Background-Diabetes mellitus (DM) and cardiovascular disease are associated with dyslipidemia, but the detailed lipid molecular pattern in both diseases remains unknown. Methods and Results-We used shotgun mass spectrometry to determine serum levels of 255 molecular lipids in 316 controls, 171 DM, and 99 myocardial infarction (MI) events from a cohort derived from the Malmo Diet and Cancer study. Orthogonal projections to latent structures analyses were conducted between the lipids and clinical parameters describing DM or MI. Fatty acid desaturases (FADS) and elongation of very long chain fatty acid protein 5 (ELOVL5) activities were estimated by calculating product to precursor ratios of polyunsaturated fatty acids in complex lipids. FADS genotypes encoding these desaturases were then tested for association with lipid levels and ratios. Differences in the levels of lipids belonging to the phosphatidylcholine and triacylglyceride (TAG) classes contributed the most to separating DM from controls. TAGs also played a dominating role in discriminating MI from controls. Levels of C18:2 fatty acids in complex lipids were lower both in DM and MI versus controls (DM, P=0.004; MI, P=6.0E-06) at least due to an acceleration in the metabolic flux from C18: 2 to C20:4 (eg, increased estimated ELOVL5: DM, P=0.02; MI, P=0.04, and combined elongase-desaturase activities: DM, P=3.0E-06; MI, P=2.0E-06). Minor allele carriers of FADS genotypes were associated with increased levels of C18: 2 (P <= 0.007) and lower desaturase activity (P <= 0.002). Conclusions-We demonstrate a possible relationship between decreased levels of C18: 2 in complex lipids and DM or MI. We thereby highlight the importance of molecular lipids in the pathogenesis of both diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- diabetes mellitus
- fatty acid desaturase
- genotype
- lipid metabolites
- myocardial infarction
- CORONARY-ARTERY-DISEASE
- OF-FUNCTION MUTATIONS
- DIETARY FATTY-ACIDS
- CARDIOVASCULAR EVENTS
- DESATURASE ACTIVITY
- VASCULAR-DISEASE
- LINOLEIC-ACID
- GENE-CLUSTER
- RISK
- PATHOPHYSIOLOGY
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kjellqvist, S.
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Klose, C.
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Surma, M. A.
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Hindy, G.
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Mollet, I. G.
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Johansson, A.
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show more...
-
Chavaux, P.
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Gottfries, Johan ...
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Simons, K.
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Melander, O.
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Fernandez, C.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Journal of the A ...
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University of Gothenburg