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Cancer risk in pati...
Cancer risk in patients with spondyloarthritis treated with TNF inhibitors: a collaborative study from the ARTIS and DANBIO registers
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- Hellgren, K. (författare)
- Karolinska Institutet,Karolinska Institute
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- Dreyer, L. (författare)
- University of Copenhagen
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- Arkema, E. V. (författare)
- Karolinska Institutet,Karolinska Institute
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- Glintborg, B. (författare)
- University of Copenhagen
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- Jacobsson, Lennart T. H., 1954 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Kristensen, Lars Erik (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,University of Copenhagen,Skåne University Hospital
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- Feltelius, N. (författare)
- Swedish medical products agency
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- Hetland, M. L. (författare)
- University of Copenhagen
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- Askling, J. (författare)
- Karolinska Institutet,Karolinska Institute
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Artis Study Grp; DANBIO Study Grp, Artis Study Grp; DANBIO Study Grp (författare)
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- Baecklund, Eva (författare)
- Uppsala universitet,Reumatologi
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(creator_code:org_t)
- 2016-05-04
- 2017
- Engelska.
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 76:1, s. 105-111
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Abstract
Ämnesord
Stäng
- Background Safety data on cancer risks following tumour necrosis factor alpha inhibitors (TNFi) in patients with spondyloarthritis (SpA) (here defined as ankylosing spondylitis (AS), undifferentiated spondarthropaties (SpA UNS), psoriatic arthritis (PsA)) are scarce. Our objective was to assess risks for cancer overall and for common subtypes in patients with SpA treated with TNFi compared with TNFi-naive patients with SpA and to the general population. Methods From the Swedish (Anti-Rheumatic Therapy in Sweden (ARTIS)) and Danish (DANBIO) biologics registers, we assembled 8703 (ARTIS=5448, DANBIO=3255) patients with SpA initiating a first TNFi 2001-2011. From the Swedish National Patient and Population Registers we assembled a TNFi-naive SpA cohort (n=28,164) and a Swedish age-matched and sex-matched general population comparator cohort (n=131 687). We identified incident cancers by linkage with the nationwide Swedish and Danish Cancer Registers 2001-2011, and calculated age-standardised and sex-standardised incidence ratios as measures of relative risk (RR). Results Based on 1188 cancers among the TNFi-naive patients with SpA, RR of cancer overall was 1.1 (95% Cl 1.0 to 1.2). Based on 147 cancers among TNFi initiators with SpA, RR versus TNFi-naive was 0.8 (95% CI 0.7 to 1.0) and results were similar for AS and PsA when analysed separately. Site-specific cancer RRs: prostate 0.5 (95% CI 0.3 to 0.8), lung 0.6 (95% CI 0.3 to 1.3), colorectal 1.0 (95% CI 0.5 to 2.0), breast 1.3 (95% Cl 0.9 to 2.0), lymphoma 0.8 (95% CI 0.4 to 1.8) and melanoma 1.4 (95% CI 0.7 to 2.6). Conclusions In patients with SpA, treatment with TNFi was not associated with increased risks of cancer, neither overall nor for the six most common cancer types.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- tumor-necrosis-factor
- rheumatoid-arthritis
- ankylosing-spondylitis
- psoriatic-arthritis
- serious infections
- biologics register
- colorectal-cancer
- clinical-trials
- factor therapy
- malignancies
- Rheumatology
- B
- 2009
- Kvalitet och innehall i patientregistret. national Board of Health and Welfare
- Ankylosing Spondylitis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Hellgren, K.
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Dreyer, L.
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Arkema, E. V.
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Glintborg, B.
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Jacobsson, Lenna ...
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Kristensen, Lars ...
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visa fler...
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Feltelius, N.
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Hetland, M. L.
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Askling, J.
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Artis Study Grp; ...
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Baecklund, Eva
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Reumatologi och ...
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MEDICIN OCH HÄLS ...
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och Cancer och onkol ...
- Artiklar i publikationen
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Annals of the Rh ...
- Av lärosätet
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Göteborgs universitet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet