Yeast buddies helping to unravel the complexity of neurodegenerative disorders

• Neurodegenerative disorders have a profound effect on the quality of life of patients and their environment. However, the development of adequate therapies requires accurate understanding of the underlying disease pathogenesis. On that account, yeast models can play an important role, as they enable the elucidation of the mechanisms leading to neurodegenerative disorders. Furthermore, by using so-called humanized yeast systems, the findings in yeast can be interpolated to humans. In this review, we will give an overview of the current body of knowledge on the use of yeast models with regard to Huntington's, Parkinson's and Alzheimer's disease. In addition to the results, obtained with the baker's yeast Saccharomyces cerevisiae, we also consider the existing literature on the less common but promising fission yeast Schizosaccharomyces pombe. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Ämnesord

NATURVETENSKAP  -- Biologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Nyckelord

Alzheimer

Parkinson

Huntington

Prion

Yeast

amyloid precursor protein

neuronal intranuclear inclusions

alpha-synuclein aggregation

mutant huntingtin fragment

familial

parkinson-disease

cyclin-dependent kinase-5

gamma-secretase activity

2 analytical platforms

yac128 mouse model

p-type atpase

Cell Biology

Geriatrics & Gerontology

hilling g

1995

human molecular genetics

v4

p1365

ernoff yo

1995

science

v268

p880

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)