The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper

• Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the autisms [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as steroid metabolism and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. Autism Res2017. (c) 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. Autism Res 2017, 10: 1022-1044. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

autism

cholesterol

cortisol

estrogens

steroid hormones

testosterone

vitamin D

LEMLI-OPITZ-SYNDROME

CORTISOL CIRCADIAN-RHYTHMS

MALE BRAIN THEORY

VITAMIN-D

TUBEROUS SCLEROSIS

INTRANASAL OXYTOCIN

FUNCTIONING

CHILDREN

SYSTEMATIC REVIEWS

SALIVARY CORTISOL

PRISMA STATEMENT

Publikations- och innehållstyp

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