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NOX2-dependent immu...
NOX2-dependent immunosuppression in chronic myelomonocytic leukemia
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- Aurelius, Johan, 1980 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Hallner, Alexander, 1990 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Werlenius, Olle (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Riise, Rebecca E, 1987 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Mollgard, L. (författare)
- Sahlgrenska University Hospital
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- Brune, M. (författare)
- Sahlgrenska University Hospital
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- Hansson, Markus (författare)
- Lund University,Lunds universitet,Skåne University Hospital
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- Martner, Anna, 1979 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Bergh Thorén, Fredrik, 1976 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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- Hellstrand, Kristoffer, 1956 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center
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(creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: Journal of Leukocyte Biology. - 0741-5400 .- 1938-3673. ; 102:2, s. 459-466
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Chronic myelomonocytic leukemia (CMML) is a myeloproliferative and myelodysplastic neoplasm with few treatment options and dismal prognosis. The role of natural killer (NK) cells and other antileukemic lymphocytes in CMML is largely unknown. We aimed to provide insight into the mechanisms of immune evasion in CMML with a focus on immunosuppressive reactive oxygen species (ROS) formed by the myeloid cell NADPH oxidase-2 (NOX2). The dominant population of primary human CMML cells was found to express membrane-bound NOX2 and to release ROS, which, in turn, triggered extensive PARP-1-dependent cell death in cocultured NK cells, CD8(+) T effector memory cells, and CD8(+) T effector cells. Inhibitors of ROS formation and scavengers of extracellular ROS prevented CMML cell-induced lymphocyte death and facilitated NK cell degranulation toward Ab-coated, primary CMML cells. In patients with CMML, elevation of immature cell counts (CD34(+)) in blood was associated with reduced expression of several NK cell-activating receptors. We propose that CMML cells may use extracellular ROS as a targetable mechanism of immune escape.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- CMML
- reactive oxygen species
- NK cells
- ROS
- T cells
- MDS/MPN
- acute myeloid-leukemia
- natural-killer-cells
- reactive oxygen
- metabolites
- nk cells
- histaminergic regulation
- cytotoxic lymphocytes
- oxidative stress
- free survival
- expression
- apoptosis
- Cell Biology
- Hematology
- Immunology
- llin p
- 1991
- cell biochemistry and function
- v9
- p29
- Cell Separation
- Flow Cytometry
- Humans
- Immunophenotyping
- Leukemia, Myelomonocytic, Chronic
- Membrane Glycoproteins
- Microscopy, Confocal
- Myeloid Cells
- NADPH Oxidase
- Reactive Oxygen Species
- Tumor Escape
- Journal Article
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Aurelius, Johan, ...
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Hallner, Alexand ...
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Werlenius, Olle
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Riise, Rebecca E ...
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Mollgard, L.
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Brune, M.
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Hansson, Markus
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Martner, Anna, 1 ...
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Bergh Thorén, Fr ...
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Hellstrand, Kris ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Journal of Leuko ...
- Av lärosätet
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Göteborgs universitet
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Lunds universitet